Prenatal infections remain a serious problem for the modern medicine, despite the obvious successes reached last decades. Pathogen capable to cause such an infection widely circulate among the human population. Serious after-effects for obstetric anamnesis and the long-term effects for the development of the child was shown.

Similar clinical symptoms of the fetal infections at newborns practically exclude the possibility to arrive at diagnosis only on the basis of a clinical picture. In this connection the role of the laboratory researches, especially specific laboratory diagnostics for the purpose of as much as possible fast statement of the diagnosis increases.

In laboratory diagnostics of the fetal infections all spectrum of diagnostic methods is applied: from various variants of microscopy and pathogen isolation on cell culture, up to enzyme immunoassay testing and molecular-biological diagnostic methods (PCR, LCR, NASBA, etc.).

But only diagnostics based on serological blood markers definition is simple enough and extremely important for fetal infections precaution at pregnant women. These methods include enzyme immunoassay (EIA), chemiluminescence immunoassay (CLIA) and other immunological analyses. By results of serum research on specific IgG and IgM antibodies it is possible to establish the woman immune status concerning fetal infections and to predict group and degree of risk. Now a days ELISA is a unique screening method, allowing to survey large population groups for definition the risk of contamination by fetal infections and after vaccination immune status.