№ 400-07
PharmacoGENE-VKORC1
Description
Diagnostic kit «PharmacoGENE-VKORC1» is aimed for genetic diagnostics of individual susceptibility for indirect anticoagulants (warfarin).
Allelic polymorphism -1639G/A in VKORC1 gene, which encodes vitamin K enzyme – epoxide reductase complex, an aim for indirect anticoagulants, significantly influences gene expression level and increases an anticoagulant effect.
Analysis of allelic polymorphisms in VKORC1 gene is made by means of Real-Time PCR.
It is recommended to use «PharmacoGENE-VKORC1» diagnostic kit together with «PharmacoGENE-CYP2C9».
Analysis is intended for:
• Adjustment of primary indirect anticoagulants dosage for patients with high risk of thrombosis, thrombotic complications or ischemic stroke development;
• Adjustment of drug dosage for patients diagnosed with ciliary arrhythmia, those who went through heart valve replacement surgery;
• Adjustment of drug dosage for postexposure prophylaxis of cardiovascular episodes at patients who had acutec coronary syndrome;
• Adjustment of drug dosage for patients with unwanted reactions for medication in family or personal anamnesis.