№ 400-05
TromboGENE
Description
Diagnostic kit «TromboGENE» is aimed for genetic diagnostics of hereditary trombophilia as well as the evaluation of a risk of a deep vein thrombosis and pulmonary artery thromboembolism.
The most important risk factors of hereditary trombophilia development are single nucleotide polymorphism (SNP) +1691G/A in F5 gene (Leiden mutation), which leads to fibrin accumulation and development of a blood clot, and SNP + 20210G/A in F2 (prothrombin) gene, that enhances the gene expression, which by-turn leads to a prothrombin concentration extension in blood as well as blood clots active development.
Analysis of SNP’s in F5 and F2 genes is made by means of Real-Time PCR.
Analysis is intended for:
• Patients with family anamnesis of thrombosis;
• Women planning pregnancy;
• Patients before operative surgical intervention;
• Patients who had been diagnosed with thrombosis or embolism at the age under 50;
• Patients who had first episode of thrombosis localized non-typically;
• Repeatable episodes of thrombosis and embolis in anamnesis;
• Patients who had first episode of thrombosis associated with pregnancy, childbirth, taking oral contraceptives, hormonal substitution therapy;
• Women who had spontaneous abortion in second or third trimester of pregnancy for unknown reasons;
• Prevention of thrombotic complications in case of oral contraceptives taking or hormonal substitution therapy planning;
• Prevention of thrombotic complications in case of continuous immobilization.