IgE antibodies are a special class of immunoglobulins that are produced by the immune system in response to antigens.
Once secreted by specially programmed B-lymphocytes, IgE circulates in the bloodstream until it becomes attached to the surface membranes of mast cells and basophils present in the epithelial surfaces of the body, such as the respiratory and gastrointestinal tracts and the skin.
Upon re-exposure, some allergens cross-link the membrane-bound corresponding specific IgE and trigger the release of several inflammatory mediators including histamine, leukotrienes, prostaglandins, and proteases, thereby producing the familiar signs and symptoms of allergies.
Determination concentration specific IgE is very important in the diagnostic of allergy diseases, because it helps to find a reason of disease, specific allergen.